Moderna announces data from Phase 1 mRNA cancer vaccine study
Category: #health  | By Nikita Chaurasia  | Date: 2019-06-03 |
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Moderna announces data from Phase 1 mRNA cancer vaccine study

The data revealed Moderna’s mRNA personalized cancer vaccine (PCV) mRNA-4157 to be well-tolerated at all tested doses and elicited neoantigen-specific T-cell responses.

Massachusetts-based biotechnology firm, Moderna, Inc. has recently announced interim data from its ongoing Phase 1 clinical study in patients with both unresected (advanced) and resected (adjuvant) solid tumors.

According to reports, the data showed Moderna’s mRNA PCV (personalized cancer vaccine) mRNA-4157, given separately or in conjunction with Merck’s pembrolizumab (KEYTRUDA®), to be well-tolerated at all tested doses and elicited neoantigen-specific T-cell responses. Furthermore, there were no vaccine-related SAEs (serious adverse events) reported for PCV when directed to patients as a monotherapy or in conjunction with pembrolizumab.

Demonstrated at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, the study showed Moderna’s mRNA platform’s immunogenicity for creating PCVs. In addition, the clinical activity was observed in some patients receiving mRNA-4157 in combination with pembrolizumab.

Reports cite that these tolerability, safety and immunogenicity data and the observed initial clinical activity support Moderna’s randomized Phase 2 study examining pembrolizumab in combination with a 1 mg dose of mRNA-4157, compared to pembrolizumab alone, for the treatment of high-risk adjuvant melanoma.

Speaking on the trial, Tal Zaks, M.D., Ph.D., CMO, Moderna, said that the company is encouraged by these interim data from its PCV program, which includes designing and manufacturing of a unique vaccine for individual patient depending on their specific tumor. Zaks claims that this study validates Moderna’s mRNA PCV’s ability to elicit T-cells that are specific to the cancer mutations.

Moreover, the company has also observed early signs of clinical activity of its personalized cancer vaccine in combination with pembrolizumab, including in two patients who were prior treated with checkpoint inhibitors.

Adding further Zaks claims that the firm is looking forward to building on these learnings about immunogenicity and tolerability by assessing activity in a randomized Phase 2 study for the treatment of adjuvant melanoma.

Source Credit: https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-presentation-interim-data-phase-1-study-mrna

https://www.biospace.com/article/releases/moderna-announces-presentation-of-interim-data-from-phase-1-study-of-mrna-personalized-cancer-vaccine-at-2019-asco-annual-meeting/

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Nikita Chaurasia     twitter

Nikita Chaurasia

Having always been daft at wordplay, Nikita Chaurasia, post the completion of post-graduation, commenced her journey into the content generation cosmos. Endowed with a professional MBA degree in Advertising and Public Relations, Nikita strives to integrate her creativ...

Read More..

More News By Nikita Chaurasia

Dr. Reddy’s becomes India’s second biggest drugmaker by sales

Dr. Reddy’s becomes India’s second biggest drugmaker by sales

By Nikita Chaurasia

Dr. Reddy's Laboratories Ltd. and Cipla Ltd. surpassed Aurobindo Pharma to rank as the 2nd and 3rd largest drug manufacturers in India by sales in the three months that ended on September 30. This was the first change in the pecking order of the ...

UK’s business confidence drops to its lowest point since 2009

UK’s business confidence drops to its lowest point since 2009

By Nikita Chaurasia

According to recent data, business confidence in the UK dropped to 18% in October, which was its lowest level in at least 13 years. In contrast, however, net balances of confidence stood at 28% in June and 56% in February, according to Accenture and ...

Attero aims to increase recycling capacity, plans for IPO in 2025

Attero aims to increase recycling capacity, plans for IPO in 2025

By Nikita Chaurasia

Attero Recycling, a firm that recycles electronic waste, is aiming to launch an initial public offering (IPO) in 2025, according to its Co-Founder and CEO Nitin Gupta. As per Gupta, the company is currently debating whether to list its shares in I...