Imvax unveils positive results from clinical trial of IGV-001 vaccine
Category: #health  By Nikita Chaurasia  Date: 2019-04-01
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Imvax unveils positive results from clinical trial of IGV-001 vaccine

Clinical-stage biotechnology company Imvax, Inc., committed to creating novel patient-specific vaccines and immunotherapy strategies, has reportedly attained positive results from an ongoing Phase 1b clinical trial that proves treatment with IGV-001, the firm’s new autologous tumor cell vaccine, outdid standard of care (SOC) with progression-free survival (PFS) and prolonged overall survival (OS) among patients newly diagnosed glioblastoma multiforme (GBM).

The results were reportedly demonstrated through an oral presentation over the session of Advances in Novel Immunotherapeutic held at the American Association for Cancer Research Annual Meeting 2019, backs the consistent development of a new immunotherapy paradigm for treating GBM.

Anthony Alfred Chiurco, MD, Neurological Surgery Professor, Vice Chair of Clinical Services at Jefferson University’s Vickie and Jack Farber Institute for Neuroscience and David W. Andrews, M.D., Imvax’s Co-founder, Interim CEO, and Chief Medical Officer, said that the results evidently demonstrate that this new investigational vaccine displays promise when compared to currently practiced standard of care therapies.

The Phase 1b trial assessed the safety and efficiency of the autologous vaccine IGV-001, developed from patients’ tumor cells and an antisense formula, in newly diagnosed adult GBM patients, cite sources close to the development.

The trial reportedly involved thirty-three patients who received one of four vaccine exposures, while SOC treatment, for instance, radiotherapy, and temozolomide was introduced four to six weeks post vaccine administration. The main endpoint was safety, while tumor response was the secondary endpoint. Exploratory goals comprised of an assessment of OS, PFS, and immune markers, reported sources. In addition, a historical comparator group consisting of 35 newly diagnosed patients with GBM treated at the same center assessed SOC alone, stated sources familiar with the trial.

The treatment with IGV-001 was well tolerated with 15 of 33 patients experiencing no tumor growth as of March 1, 2019. Additionally, the cohort treated with the highest vaccine dose displayed an improvement of 7.3 months in OS and 3.5 months in PFS against SOC treatment alone, reported sources.
 

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Nikita Chaurasia     twitter

Nikita Chaurasia

Having always been daft at wordplay, Nikita Chaurasia, post the completion of post-graduation, commenced her journey into the content generation cosmos. Endowed with a professional MBA degree in Advertising and Public Relations, Nikita strives to integrate her creativ...

Read More..

More News By Nikita Chaurasia

U.K.’s competition regulator might look into the music streaming space

U.K.’s competition regulator might look into the music streaming space

By Nikita Chaurasia

The Competition and Markets Authority of the U.K. has revealed plans to launch a probe targeting the country’s music streaming market to ascertain if it is sufficiently consumer-centric and competitive. The announcement came after a U.K. parli...

India’s vaccination drive slows down as dose gap holds back output

India’s vaccination drive slows down as dose gap holds back output

By Nikita Chaurasia

India’s vaccination efforts have reportedly slowed down despite stockpiling vaccines as authorities are maintaining a more than usual gap between two shots. This is a part of the strategy to boost vaccine coverage in the country. The domestic ...

McDonald’s to test McPlant meatless burger at eight U.S. restaurants

McDonald’s to test McPlant meatless burger at eight U.S. restaurants

By Nikita Chaurasia

The McPlant patty is developed in collaboration with Beyond Meat Inc. It will be prepared using vegetarian ingredients like peas, potatoes, and rice. McDonald’s will reportedly start offering its first vegetarian option in the U.S., the ne...