Ascentage Pharma declares first patient dosed in APG-2575 trial
Category: #health  | By Nikita Chaurasia  | Date: 2019-07-15 |
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Ascentage Pharma declares first patient dosed in APG-2575 trial

APG-2575 created by Ascentage Pharma is one of the rare Bcl-2 selective inhibitors in active clinical studies apart from Venetoclax.

Ascentage Pharma has reportedly announced that it has dosed the first patient in a phase I medical study of APG-2575, a new Bcl-2 selective inhibitor, for treating hematologic malignancies in China. The company also has a continuing multi-center phase I APG-2575 dose-escalation trial as a single agent in Australia and the United States. APG-2575 is anticipated to potentially be the first Bcl-2 inhibitor made in China.

For the record, APG-2575 is an innovative, orally managed Bcl-2 selective inhibitor. It is created to heal hematologic malignancies through selective blocking Bcl-2 to recreate the regular apoptosis process in cancer cells.

Reportedly, the founding member of the Bcl-2 family proteins is Bcl-2. The Bcl-2 family proteins are most prominent for their significant roles in regulating apoptosis by the development of heterodimers through pro-apoptotic proteins (BAD, BIM and many others). It is complicated to create a drug which affects Bcl-2 family protein due to the hydrophobic and very large Bcl-2 protein interfaces. The promoted Bcl-2 inhibitor venetoclax/ABT-199 accepted by the U.S. FDA in April 2016 has legalized the medical basis for more targeted drug development. APG-2575 created by Ascentage Pharma is one of the rare Bcl-2 selective inhibitors in active clinical studies apart from Venetoclax.

Sources claimed that the Phase I trial is created to evaluate the tolerance and safety of APG-2575 in patients enduring hematologic malignancies. The trial is also designed to check the recommended Phase II dose (RP2D) or maximal tolerated dose (MTD) of APG-2575. Patients with acute Non-Hodgkin's Lymphoma (NHL) and Acute Myelogenous Leukemia (AML) have been Included in this trial. Presently, the first enrolled patient has been medicated during the initial stage of dose-escalation.

Ascentage Pharma has reportedly released numerous preclinical research outcomes of APG-2575 during the annual meeting of 2019 American Association for Cancer Research (AACR). The results have shown the potential in combination therapy.

Source credit:

https://www.prnewswire.com/news-releases/ascentage-pharma-announces-first-patient-dosed-in-phase-i-clinical-trial-of-apg-2575-in-china-as-the-first-china-made-bcl-2-inhibitor-300884516.html

https://www.tullahomanews.com/news/business/ascentage-pharma-announces-first-patient-dosed-in-phase-i-clinical/article_8c4cdc27-db63-59f8-9ce9-dd301581f9fc.html

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Nikita Chaurasia     twitter

Nikita Chaurasia

Having always been daft at wordplay, Nikita Chaurasia, post the completion of post-graduation, commenced her journey into the content generation cosmos. Endowed with a professional MBA degree in Advertising and Public Relations, Nikita strives to integrate her creativ...

Read More..

More News By Nikita Chaurasia

EasyJet sees a rise in bookings as customers plan their next vacations

EasyJet sees a rise in bookings as customers plan their next vacations

By Nikita Chaurasia

British multinational low-cost airline group, EasyJet, has reported a record surge in bookings for the month of January as people prioritized their travel plans for the coming year. The news comes as airlines world over start to show signs that they&...

Dr. Reddy’s becomes India’s second biggest drugmaker by sales

Dr. Reddy’s becomes India’s second biggest drugmaker by sales

By Nikita Chaurasia

Dr. Reddy's Laboratories Ltd. and Cipla Ltd. surpassed Aurobindo Pharma to rank as the 2nd and 3rd largest drug manufacturers in India by sales in the three months that ended on September 30. This was the first change in the pecking order of the ...

UK’s business confidence drops to its lowest point since 2009

UK’s business confidence drops to its lowest point since 2009

By Nikita Chaurasia

According to recent data, business confidence in the UK dropped to 18% in October, which was its lowest level in at least 13 years. In contrast, however, net balances of confidence stood at 28% in June and 56% in February, according to Accenture and ...