Spring Bank refrains from dosing patients in Inarigivir clinical trials
Category: #health  By Mateen Dalal  Date: 2019-12-28
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Spring Bank refrains from dosing patients in Inarigivir clinical trials

Clinical-stage biopharmaceutical company, Spring Bank Pharmaceuticals, Inc. has reportedly stopped patient dosing and enrollment in its Phase 2b CATALYST studies that aim at evaluating the use of inarigivir soproxil 400mg for treating chronic hepatitis B virus (HBV). In addition to this, the company has also discontinued dosing and enrollment of patients with chronic HBV in all other inarigivir studies, claim reports.

Apparently, the move comes on heels after the clinical trials observed three patients participating in the clinical trial showing evidence of hepatocellular dysfunction (liver failure) and an increase in ALT (alanine transaminase) potentially consistent with liver injury instead of immune flares.

Sources cite that the company is currently investigating and analyzing the data to gain a better understanding of the potential causes of these side effects and is further examining the safety data across around 100 patients who have already been dosed with inarigivir.

Speaking on the issue, Martin Driscoll, President & Chief Executive Officer, Spring Bank, said that their firm has stopped enrolling and dosing patients in the CATALYST 2 trial due to caution based on laboratory data from subjects. They are indeed disappointed to stop its ongoing Phase 2 inarigivir trials, however, is ensuring patient safety and care as its topmost priority.

Driscoll added that working with the members of its clinical trial investigators, Data Safety Monitoring Board and experts, Spring Bank will review all the available information recorded from the CATALYST 2 trial as well as will investigate other inarigivir trials at the 400mg dose to determine the appropriate path forward for these trials.

About Spring Bank Pharmaceuticals, Inc. 

It is a biopharmaceutical company engaged in the development and discovery of novel therapeutics using its exclusive small molecule nucleotide platform. The company formulates its compounds to target and regulate the activity of specific proteins involved in various disease states.

Sources Credit: https://ir.springbankpharm.com/news-releases/news-release-details/spring-bank-stops-dosing-inarigivir-patients-phase-2-program?field_nir_news_date_value[min]=2019

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal     twitter

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More..

More News By Mateen Dalal

China unveils plans to reinforce stringent safety standards for EVs

China unveils plans to reinforce stringent safety standards for EVs

By Mateen Dalal

This news comes amid rising incidences of battery fires and breaks failures. China will require automakers to have a 24-hour emergency response system to address major accidents. China is planning to reinforce strict safety standards for electri...

Facebook testing new option for cross-posting content to Instagram

Facebook testing new option for cross-posting content to Instagram

By Mateen Dalal

Facebook, Inc is reportedly testing an option that will allow users to cross-post their photos, videos, and other posts on their Instagram. It already has the feature to let people cross-post their Instagram content to Facebook. This upcoming featur...

General Motors to recoup USD 1.9 Bn from LG spent on Bolt EV recall

General Motors to recoup USD 1.9 Bn from LG spent on Bolt EV recall

By Mateen Dalal

GM will recover almost all the costs from the recall of its Bolt EV models. Despite the EV battery manufacturing mishap from LG, the two companies will continue to work together. General Motors (GM) has agreed to recover around USD 1.9 billion f...