Eloxx Pharmaceuticals initiates Phase 2 clinical trial for ELX-02
Category: #health  By Mateen Dalal  Date: 2019-08-07
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Eloxx Pharmaceuticals initiates Phase 2 clinical trial for ELX-02

Six patients will be registered for the trial and will be treated with ELX-02 for four weeks with three rising dose levels.

Eloxx Pharmaceuticals, Inc., an American biopharmaceutical company focused on the discovery and development of novel therapeutics to treat inherited retinal disorders, cystinosis, cystic fibrosis and other diseases caused by nonsense mutations preventing production of functional proteins, has recently shared that it has started with the Phase 2 clinical trial for ELX-02 (study 003) in cystinosis in Canada.

According to reliable sources, study 003 is a single arm, open label study developed to assess the tolerability, safety, pharmacokinetics (PK) and PD (pharmacodynamics) of subcutaneous (SC) ELX-02 in people with nephropathic cystinosis with minimum 1 nonsense mutation in the cystinosin gene. 

Speaking on the announcement, Dr. Paul Goodyer, Professor of Pediatrics, McGill University, said that the company is excited to initiate ELX-02 to cystinosis patients, a new potential treatment option which has recorded encouraging results in animal and cellular models with dose-dependent reductions in white blood cell cystine levels, a biomarker used to predict clinical benefit and to monitor cysteamine therapy.

He said that there is a high unmet medical need in cystinosis which is identified in infancy, and the emergence of new therapeutic options that could alter the course of this disease could drastically improve the lives of patients.

According to Dr. Greg Williams, PhD, COO, Eloxx Pharmaceuticals, their firm is delighted to initiate the Phase 2 clinical trial for ELX-02 in cystinosis patients with at least one nonsense mutation in Canada and are grateful for the non-dilutive funding and support it has received for this clinical trial from Genome Canada and Genome Quebec.

He added that the company is looking forward to reporting top line data from this trial in early Q4 2019. The firm believes the initial results from their renal impairment study, as well as the results till date offer support both for continuing their clinical development programs and assessing the aptness of their ERSG library for advancement in additional renal disorders, involving cystinuria and autosomal dominant polycystic kidney disease, cites Williams.

Source Credit: https://investors.eloxxpharma.com/news-releases/news-release-details/eloxx-pharmaceuticals-announces-initiation-phase-2-clinical

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal     twitter

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More..

More News By Mateen Dalal

General Motors to recoup USD 1.9 Bn from LG spent on Bolt EV recall

General Motors to recoup USD 1.9 Bn from LG spent on Bolt EV recall

By Mateen Dalal

GM will recover almost all the costs from the recall of its Bolt EV models. Despite the EV battery manufacturing mishap from LG, the two companies will continue to work together. General Motors (GM) has agreed to recover around USD 1.9 billion f...

Tata Motors records 25% jump in global sales in second quarter of 2021

Tata Motors records 25% jump in global sales in second quarter of 2021

By Mateen Dalal

The automaker’s annual wholesale growth has been around 24%. The company saw a 10% rise in passenger car sales during Q2 2021, as compared to the same period in 2020. Tata Motors Limited reported substantial growth in Q2 2021, with its glo...

Carbon Budgets for corporate business travels to hit airlines: Report

Carbon Budgets for corporate business travels to hit airlines: Report

By Mateen Dalal

With major companies considering ways to reduce carbon emissions from corporate travel, airlines are preparing for a setback in business-class travel, which is an important revenue driver according to industry experts and executives. The airline ind...