Cellectis reveals POC for smart T-cells that recognize tumors
Category: #health  By Mateen Dalal  Date: 2019-11-15
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Cellectis reveals POC for smart T-cells that recognize tumors

Cellectis, a French biopharmaceutical company that aims to innovate immunotherapies based on gene-edited allogeneic CAR T-cells, recently revealed a report issued in Nature Communications that explains a proof-of-concept (POC) for cell pathway’s rewiring to produce extremely intelligent T-cells which could identify cancerous tumors and create a micro secretion of therapeutic proteins.

This advancement could eventually enhance the capability of T-cells to fight cancer and redesign the tumor microenvironment. Moreover, by using gene editing procedures to rewire the CD25, PD1 and TCRα genes, the study allowed CAR T-cells to micro secrete the IL-12, pro-inflammatory cytokine, in a tumor.

Reportedly, this procedure was done in a time-dependent manner which would further lay the foundation for the next generation of highly active, potentially safer and tightly controlled CAR T-cell therapies.

Speaking on the move, Dr. Philippe Duchateau, Ph.D., Chief Scientific Officer, Cellectis, said that the conversation near the tumor microenvironment has become a trending issue in the CAR T-cell space, and with the current developments in gene-editing technologies, particularly TALEN®, has opened the possibility to manipulate T-cell’s way to regulate itself to adjust with its environment.

Duchateau added that, with successively rewiring their natural regulatory activities and seamless modification of various genes, this method would trigger T-cells to produce therapeutic proteins of interest in a strongly localized and controlled manner. 

Additionally, the company has changed the current T-cells into powerful and precise micro-robots which could spray IL-12 precisely onto cancer cells. This would prevent the potential toxicity of IL-12’s systemic injection while improving CAR-T activity.

Earlier this year, Cellectis had made headlines when it revealed that it has signed a manufacturing service agreement that covers clinical manufacturing of the company’s allogeneic UCART drug candidates pursuing hematological malignancies. 

Reportedly, the manufacturing is expected to be conducted at Lonza's GMP facility which is located in Geleen, Netherlands.

Source Credit: https://www.cellectis.com/en/press/cellectis-publishes-creation-of-smart-car-t-cells-for-potentially-safer-more-effective-treatments-for-cancer-in-nature-communications/

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal     twitter

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More..

More News By Mateen Dalal

Sony sells 10 million Play Station consoles just 294 days after launch

Sony sells 10 million Play Station consoles just 294 days after launch

By Mateen Dalal

Sony has reportedly managed to sell around 10 million Play Station 5 consoles in 249 days after its launch in November 2020. The company had sold approximately 7.8 million PS5 units as of April 2021. In comparison, approximately 10 million units of ...

Chevrolet Camaro could be replaced by a potential all-electric sedan

Chevrolet Camaro could be replaced by a potential all-electric sedan

By Mateen Dalal

Reportedly, General Motors Company is planning to replace the Chevrolet Camaro with an all-electric performance sedan in a few years with the existing model likely to be phased out by 2024. There have many reports about discontinuing the Camaro&rsqu...

Sequoia India launches Spark Fellowship to support female entrepreneurs

Sequoia India launches Spark Fellowship to support female entrepreneurs

By Mateen Dalal

The Spark fellowship program is for women entrepreneurs in India and Southeast Asia. The year-long program is aimed at bringing more gender diversity and supporting startups led by women. Sequoia Capital has recently revealed the launch of a yea...