Cantargia confirms enrollment in Phase IIa trial for CAN04 monotherapy
Category: #health  | By Mateen Dalal  | Date: 2019-07-06 |
  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn

Cantargia confirms enrollment in Phase IIa trial for CAN04 monotherapy

All the 20 patients for the monotherapy arm of the trial have begun treatment with 10 mg/kg dosage level

Swedish biotech firm Cantargia has reportedly announced full recruitment of CAN04 monotherapy arm in an existing Phase IIa clinical study in cancer patients.

Sources with knowledge on the matter informed that CAN04 (nidanilimab) is an antibody from Cantargia which is being investigated in a three-armed open label Phase IIa trial CANFOUR. Under this, CAN04 is evaluated as monotherapy or in chemotherapy combinations in pancreatic cancer (PDAC) or non-small cell lung cancer (NSCLC) patients.

All the 20 patients for the monotherapy arm of the trial have begun treatment with 10 mg/kg dose. The Safety, overall, has been in line with Phase I results. Outcome of the monotherapy, including efficacy and biomarkers are expected to be ready during fourth quarter of 2019, the sources informed.

Cantargia, on the basis of fast recruitment and good safety, is planning to utilize this opportunity to add more patients for generating safety and biomarker data at higher dosage level. Enrollment for the combination arms is also ongoing parallel to the monotherapy arm.

Sources stated that tumor biopsies have been obtained from most for the patients in the study, which were taken before and after therapy. Analyzing these biopsies will provide insights into the impact of CAN04 in the tumor microenvironment. Biomarkers would also be analyzed in the serum and the outcomes of these analyses are expected together with the efficacy results from CT-sans, sources added.

For the uninitiated, Cantargia develops pharmaceuticals based on antibodies against the interleukin 1 receptor accessory protein, or IL1RAP. IL1RAP with high functions and affinity is bound by antibody CAN04 through blockade of interleukin 1 signaling as well as ADCC. Apparently, almost 70% of PDAC patients and 80% of NSCLC patients overexpress IL1RAP on cancer cells, while in these diseases every patient has cells containing IL1RAP in the tumor microenvironment.

Source Credits: https://cantargia.com/en/press-releases/cantargia-announce-full-recruitment-of-can04-monotherapy-arm-in-ongoing-phase-iia-clinical-trial

 

  • shareshare_icon
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal     twitter

Mateen Dalal

A qualified electronics and telecommunication engineer, Mateen Dalal embarked on his professional journey working as a quality and test engineer. Harnessing his passion for content creation however, Mateen pens down industry-rich articles for ReportsGO.com and a few o...

Read More..

More News By Mateen Dalal

Oral-B & iADH partner to make oral care positive & accessible for all

Oral-B & iADH partner to make oral care positive & accessible for all

By Mateen Dalal

Oral-B, a well-known American oral hygiene products brand, has reportedly inked a partnership deal with iADH (International Association of Disability and Oral Health), in order to make oral care more positive, accessible, and inclusive for disabled p...

NEA AND SLA SIGN MOU TO SHARE GLOBAL NAVIGATION SATELLITE SYSTEM (GNSS)-DERIVED MOISTURE DATA FOR WEATHER MONITORING APPLICATION

NEA AND SLA SIGN MOU TO SHARE GLOBAL NAVIGATION SATELLITE SYSTEM (GNSS)-DERIVED MOISTURE DATA FOR WEATHER MONITORING APPLICATION

By Mateen Dalal

Singapore, 2 August 2022 – The National Environment Agency (NEA) and the Singapore Land Authority (SLA) have signed a Memorandum of Understanding (MOU) to develop the use of Global Navigation Satellite System (GNSS) data obtained from SLA&rsqu...

Baidu launches Apollo RT6; seeks expansion of its robotaxi fleet

Baidu launches Apollo RT6; seeks expansion of its robotaxi fleet

By Mateen Dalal

Baidu, a leading China-based artificial intelligence (AI) company and search engine, has reportedly uncovered its most recent electric autonomous driving vehicle. As per credible sources, the new vehicle, Apollo RT6, will be a part of the robotaxi...